TLR3, CT (APC)

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene.\n\nApplications:\nSuitable for use in Immunohistochemistry, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nImmunohistochemistry: 1:50-100\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

042877-APC

Size

200ul

Applications

ELISA, IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Allophycocyanin (APC).

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

References

Heinz, S., et al., J. Biol. Chem. 278(24):21502-21509 (2003).\nSarkar, S.N., et al., J. Biol. Chem. 278(7):4393-4396 (2003).\nMatsumoto, M., et al., Biochem. Biophys. Res. Commun. 293(5):1364-1369 (2002).\nTakami, M., et al., J. Immunol. 169(3):1516-1523 (2002).\nKadowaki, N., et al., J. Exp. Med. 194(6):863-869 (2001).

Additional Info

Human