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TLR4 (CD284, Toll-like Receptor 4, hToll)

TLR4 (CD284, Toll-like Receptor 4, hToll)

Cat no: T8050-34M

Supplier: United States Biological
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Toll-like receptors are type I transmembrane signaling receptors. They are primordial pathogen-recognition proteins that function as sentinels for the innate immune system. TLR4, also known as CD284, is a 110kD protein which is expressed on monocytes/macrophages, endothelial cells, and at low levels on B cells and granulocytes. In association with a secretory molecule, MD2, TLR4 has been recognized as critical for host recognition of bacterial LPS. This antibody is useful for flow cytometric analysis and is able to block LPS-induced cytokine production. Applications: Suitable for use in Blocking, Immunofluorescence, Flow Cytometry and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: (same/less than)2ug/10e5 cells in 100ul Immunohistochemistry: Acetone-fixed frozen Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8050-34M
Reactivities: Human, Guinea Pig
Hosts: Mouse
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type: Mab
Isotype: IgG2a,k
Purity: Purified by immunoaffinity chromatography.
References: 1. Shimazu, R., et al. 1999. J. Exp. Med. 189:1777. 2. Wang, R., et al. 2003. Hybrid Hybridomics 22:357. 3. Wang, J.E., et al. Infect. Immun. 69:2402. 4. Ishihara, S., et al. 2004 J. Immunol. 173:1406. 5. Kawahara, T., et al. 2001 Infec. Immun 69:4382. 6. Jiang, Q. et al. 2000. J. Immunol. 165:3541. 7. Sugawara, S., et al. 2001. Infect. Immun. 69:4951. 8. Chavakis, E., et al. 2007. Circ. Res. 100:204. 9. Bhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest Liver Physiol. doi:10.1152/ajpgi.00149.
Additional info: Recognizes human CD284. Species Crossreactivity: guinea pig, rhesus.

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