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TLR4 (Toll-like Receptor 4, hToll, CD284)

TLR4 (Toll-like Receptor 4, hToll, CD284)

Cat no: T8050-30C

Supplier: United States Biological
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TLR4 is an 839aa member of the Toll-like receptor (TLR) family of transmembrane proteins comprised of multiple copies of leucine rich repeats in the extracellular domain and a TIR domain. It is a widely studied, phylogenetically conserved, member playing a fundamental role in pathogen recognition and activation of innate immunity. Like its counterpart in Drosophila, TLR4 signals through adaptor molecules and mediates the production of cytokines necessary for the development of effective immunity. TLR4 belongs to the multi-protein complex of lipopolysaccharide (LPS) receptor, containing CD14, LY96 and TLR4, and is involved in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. This receptor is most abundantly expressed in placenta, spleen and in myelomonocytic subpopulation of the leukocytes. Defects in this protein have been associated with differences in LPS responsiveness. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8050-30C
Reactivities: Human, Mouse, Mollusc
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Poltorak, A. et al. Proc. Natl. Acad. Sci USA. 97:2163-2167 (2000). 2. Andonegui, G. et al. J. Clin. Invest. 111:1011-1020 (2003). 3. Muzio, M. et al. A. J. Exp. Med. 187:2097-2101 (1998). 4. Ferwerda, B. et al. Proc. Nat. Acad. Sci. 104:16645-16650 (2007).
Additional info: Recognizes human TLR4. Species Crossreactivity: baboon, chimpanzee, macaque, rhesus monkey. Species sequence homology: mouse, rat, equine, pocine, bovine, gorilla.

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