TLR5 Antibody

Cat no: 251565

Supplier: ABBIOTEC

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Description
Additional Information

Toll-like receptor 5 (TLR5) participates in the innate immune response to microbial agents. TLR5 mediates detection of bacterial flagellins. TLR5 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Individuals with a common stop codon polymorphism in position 392 are unable to mediate flagellin signaling. This polymorphism acts in a dominant fashion and is associated with susceptibility to pneumonia caused by Legionella pneumophila. Genetic variations in TLR5 are associated with resistance to systemic lupus erythematosus type 1 (SLEB1). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a comple, Xenopus/Amphibian, genetic basis.

Catalogue number:	251565
Reactivities:	Human, Mouse, Rabbit
Applications:	Immunohistochemistry
Size:	0.1 mg
Accession:	O60602
Antigen:	KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human TLR5.
Format:	Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
P type:	Rabbit Polyclonal Antibody
Isotype:	Rabbit Ig
Additional info:	TLR5; CD285;Toll-like receptor 5; Toll/interleukin-1 receptor-like protein 3; TIL3