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TLR5 (Toll Like Receptor 5, Toll-like Receptor 5 Precursor, TLR 5, TLR-5, FLJ10052, MGC126430, MGC126431, Toll/interleukin 1 Receptor-like Protein 3, TIL3)

TLR5 (Toll Like Receptor 5, Toll-like Receptor 5 Precursor, TLR 5, TLR-5, FLJ10052, MGC126430, MGC126431, Toll/interleukin 1 Receptor-like Protein 3, TIL3)

Cat no: T8050-45B

Supplier: United States Biological
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TLR5 is a 97.6kD member of the evolutionarily conserved toll-like receptor family (TLRs), expressed at high levels in the liver and detectable in small amounts in most other tissues. TLRs play an important role in the recognition of invading microbial pathogens during innate immunity, acting through adaptor molecules such as MyD88 and TRAF6. TLR5 acts via a cytokine signaling pathway to induce the activation of NF-kappaB and in turn tumor necrosis factor alpha and has been shown to recognize flagellin from both Gram-positive and Gram-negative bacteria. Applications: Suitable for use in Immunohistochemistry (paraffin) and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8050-45B
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Hayashi, F. et al. (2001) The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 410: 1099-1103. 2. Hawn, T. R. et al. (2003) A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to Legionnaire
Additional info: Recognizes human TLR5. Species Crossreactivity: mouse, rat.

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