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TLR6 (Toll Like Receptor 6, Toll-like Receptor 6 Precursor, CD286, CD286 Antigen)

TLR6 (Toll Like Receptor 6, Toll-like Receptor 6 Precursor, CD286, CD286 Antigen)

Cat no: T8050-53D

Supplier: United States Biological
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TLRs play an important role in the recognition of invading microbial pathogens during innate immunity, acting through adaptor molecules such as MyD88 and TRAF6. TLR6 acts via a cytokine signaling pathway to induce the activation of NF-kappaB, through the formation of dimers with TLR2 (CD282) which coordinate macrophage activation by Gram-positive bacteria and zymosan. Studies have also revealed the involvement of TLR6/TLR2 dimers in apoptotic responses, through recognition of mycoplasmal lipoproteins. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: T8050-53D
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Into, T. et al. (2004) Stimulation of human Toll-like receptor (TLR) 2 and TLR6 with membrane lipoproteins of Mycoplasma fermentans induces apoptotic cell death after NF-kappaB activation. Cell Microbiol. 6: 187-199. 2. Ozinsky, A. et al. (2000) The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors. P.N.A.S 97: 13766-13771.
Additional info: Recognizes human TLR6.

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