Species: mouse - male, 11 to 13 days old
Strain: BALB/c nu/+
Receptor: follicle stimulating hormone (FSH); androgen; estrogen; progesterone
Histocompatibility: H-Y
Production: transferrin; H-Y antigen; retinol binding protein; plasminogen activator
Histopathology: normal
Note: the TM4 cell line responds to FSH with an increase in cAMP production, but does not respond to luteinizing hormone (LH); the FSH responsiveness is much reduced compared to primary Sertoli cell cultures; constitutive plasminogen activator production is low, but is stimulated by FSH and, to a greater extent, by retinoic acid; tested and found negative for ectromelia virus (mousepox)
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