Home  >  Products  >  TMEM173 (Transmembrane Protein 173, Endoplasmic Reticulum Interferon Stimulator, ERIS, FLJ38577, Mediator of IRF3 Activation, MITA, hMITA, MPYS, NET23, Stimulator of Interferon Genes Protein, STING, hSTING)
TMEM173 (Transmembrane Protein 173, Endoplasmic Reticulum Interferon Stimulator, ERIS, FLJ38577, Mediator of IRF3 Activation, MITA, hMITA, MPYS, NET23, Stimulator of Interferon Genes Protein, STING, hSTING)

TMEM173 (Transmembrane Protein 173, Endoplasmic Reticulum Interferon Stimulator, ERIS, FLJ38577, Mediator of IRF3 Activation, MITA, hMITA, MPYS, NET23, Stimulator of Interferon Genes Protein, STING, hSTING)

Cat no: T6020-50

Supplier: United States Biological
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STING is a 379aa containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (formalin fixed paraffin embedded): 5ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T6020-50
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
References: 1. Ishikawa, H. et al. Nature 455: 674-678 (2008). 2. Jin, L. et al. Molec. Cell. Biol. 28: 5014-5026 (2008).
Additional info: Recognizes human STING. Species Crossreactivity: chimpanzee, mouse, rat, rhesus monkey. Species sequence homology: equine, canine.

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