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TMEM64 Polyclonal Antibody

Cat no: CAC07629

TMEM64 Polyclonal Antibody

TMEM64 Polyclonal Antibody

Prices direct from Biomatik Corporation

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Exclusive Biosave savings/discounts

SPECIFICATIONS

Price

323.00 USD

Catalog Number

CAC07629

Size

100 micro g

Applications

IHC, WB

Hosts

Rabbit

Conjugates

Unconj

Purity

Protein G purified, >95%

Target

TMEM64

Clonality

Polyclonal

Storage Temp

Aliquot and store at -20 degrees C. Minimize freezing and thawing.

Research Area

For research use only. Not for diagnostic procedures.

Shipping Temp

Blue ice

Additional Info

Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1.

Alternative Names

Transmembrane protein 64,TMEM64

SUPPLIER INFO

Biomatik Corporation

Applications

ELISA

Reactivities

Hum

More info

Applications

ELISA

Reactivities

Hum

More info

Applications

ELISA

Reactivities

Hum

More info

Applications

ELISA

Reactivities

Hum

More info

Applications

ELISA

Reactivities

Hum

More info

Applications

ELISA

Reactivities

Hum

More info

Applications

ELISA

Reactivities

Hum

More info

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