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Tnfrsf-21, ID (Tnfrsf21, Tumor Necrosis Factor Receptor Superfamily Member 21)

Tnfrsf-21, ID (Tnfrsf21, Tumor Necrosis Factor Receptor Superfamily Member 21)

Cat no: D9300-64

Supplier: United States Biological
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The apoptosis is initiated via two distinct signaling mechanisms, known as the cell-intrinsic and cell-extrinsic pathways, control activation of the proapoptotic caspase family of cysteine proteases in both mammals and non-mammals. The intrinsic pathway responds primarily to developmental cues or cellular damage and triggers apoptosis through the Bcl-2 gene family and the initiator protease caspase-9. The extrinsic pathway mediates apoptosis in response to Fas ligand (FasL) and Apo2L/TRAIL, which signal respectively through the death domain (DD)- containing receptors Fas or death receptor (DR)4 and DR5. Eight DD-containing TNFR superfamily members were identified in zebrafish. zDR6 (Tnfrsf-21) is one of the six of these which can be matched with mammalian orthologs based on the architecture of their extracellular domains (ECDs), a dendrogram of their DDs, and conserved synteny with human counterparts. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 ELISA: 1:5000-1:20,000 Optimal dilutions to be determined by the researcher. Control Peptide: D9300-64P Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D9300-64
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Danial NN and Korsmeyer SJ (2004) Cell 116: 205-219. 2. Puthalakath H and Strasser A (2002) Cell Death Differ. 9: 505-512. 3. Eimon,P.M., et al. (2006) Cell Death Differ. 13 (10), 1619-1630.
Additional info: Recognizes zebrafish Tnfrsf-21.

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