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TNFRSFa, ID (Ovarian TNF Receptor)

TNFRSFa, ID (Ovarian TNF Receptor)

Cat no: D9300-65

Supplier: United States Biological
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The tumor necrosis factor receptor superfamily, member A (tnfrsfa) protein was previously known as ovarian tumor necrosis factor receptor (OTR). Tnfrsfa is central to positive regulation of apoptosis. It is highly expressed in the ovary and presents lightly in other tissues throughout the organism. Zebrafish homologs of mammalian Apo2 ligand/tumor necrosis factor (TNF)-related apoptosis inducing ligand (Apo2L/TRAIL) were shown in a study to bind OTR. Expression of these ligands was shown to induce apoptosis. Similarly, inhibition of OTR blocked ligand-induced apoptosis. These findings elucidate the similarity between mammalian and zebrafish tissue-specific apoptosis, both in the mechanism and the functions of homologs. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 ELISA: 1:5000-1:20,000 Optimal dilutions to be determined by the researcher. Control Peptide: D9300-65P. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: D9300-65
Reactivities: Zebrafish/Fish
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 250ul
Form: Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Goetz, FW (2006) Comp. Biochem. Physiol. B Biochem. Mol. Biol. 129(2-3):475-481. 2. Eimon, PM et al (2006) Cell Death Differ. 13(10):1619-1630.
Additional info: Recognizes zebrafish TNFRSFa.

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