Home  >  Products  >  Tnfsf10, Recombinant, Mouse (Tumor Necrosis Factor Ligand Superfamily Member 10, TNF-related Apoptosis-inducing Ligand, Protein TRAIL, CD253, Trail, A330042I21Rik, AI448571)

Tnfsf10, Recombinant, Mouse (Tumor Necrosis Factor Ligand Superfamily Member 10, TNF-related Apoptosis-inducing Ligand, Protein TRAIL, CD253, Trail, A330042I21Rik, AI448571)

Cat no: 149712


Supplier: United States Biological
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TRAIL is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptors belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic �death domain�, which activates the cell's apoptotic machinery. Recombinant murine soluble TRAIL is a 174aa polypeptide, 20kD, consisting of the TNF homologous portion of the extracellular domain of the full length TRAIL protein. Source: Recombinant protein corresponding to mouse TRAIL, expressed in E.coli. Biological Activity: Determined by the dose-dependent stimulation of MIP-2 production by mouse spleen cells using a concentration range of 10-100ng/ml. Endotoxin: <0.1ng/ug (1EU/ug) AA Sequence: MRGGRPQKVA AHITGITRRS NSALIPISKD GKTLGQKIES WESSRKGHSF LNHVLFRNGE LVIEQEGLYY IYSQTYFRFQ EAEDASKMVS KDKVRTKQLV QYIYKYTSYP DPIVLMKSAR NSCWSRDAEY GLYSIYQGGL FELKKNDRIF VSVTNEHLMD LDQEASFFGA FLIN Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: 149712
Size: 10ug
Form: Supplied as a lyophilized powder.
Purity: ~98% (SDS-PAGE and HPLC)

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