TNFSF15, Recombinant, Human (Tumor Necrosis Factor Ligand Superfamily Member 15, TNF Ligand-related Molecule 1, TL1, TL1A, Vascular Endothelial Cell Growth Inhibitor, VEGI, VEGI192A)

TL-1A belongs to the TNF superfamily of ligands. It is expressed predominantly in endothelial cells, and to a lesser extent in placenta, lung, kidney, skeletal muscle, pancreas, small intestine and colon. TL-1A inhibits endothelial cell proliferation and angiogenesis, and has been shown to induce NFkB activation, caspase activity, and apoptosis in responding cell lines. TL-1A interacts with TNFRSF25/DR3 receptor, but can also bind to a decoy receptor TNFRSF21/DR6. Recombinant human TL-1A is a 22kD polypeptide of 194aa.\n\nSource:\nRecombinant protein corresponding to human TL-1A, expressed in E.coli.\n\nBiological Activity:\nDetermined by its ability to stimulate IFN-gamma production by human PBMC using a concentration range of 10-100ng/ml. Note: Results may vary with PBMC donors.\n\nEndotoxin:\n<0.1ng/ug (1EU/ug)\n\nAA Sequence:\nQLRAQGEASV QFQALKGQEF APSHQQVYAP LRADGDKPRA HLTVVRQTPT QHFKNQFPAL HWEHELGLAF TKNRMNYTNK FLLIPESGDY FIYSQVTFRG MTSECSEIRQ AGRPNKPDSI TVVITKVTDS YPEPTQLLMG TKSVCEVGSN WFQPIYLGAM FSLQEGDKLM VNVSDISLVD YTKEDKTFFG AFLL\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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