AITRL, a member of the TNF superfamily, is expressed in endothelial cells, and signals through the AITR receptor. AITRL regulates T-cell proliferation and survival, and effectuates the interaction between T lymphocytes and endothelial cells. The AITRL gene codes for a type II transmembrane protein comprised of 177aa, including a 28aa cytoplasmic region, a 21aa transmembrane domain and a 128aa extracellular domain. Recombinant human soluble AITRL is a 14.3kD protein, containing 126aa corresponding to the extracellular domain of AITRL.
Source:
Recombinant protein corresponding to human TNFSF18, expressed in E.coli.
Biological Activity:
Determined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 1-10ng/ml. Note: Results may vary with PBMC donors.
Endotoxin:
<0.1ng/ug (1EU/ug)
AA Sequence:
ETAKEPCMAK FGPLPSKWQM ASSEPPCVNK VSDWKLEILQ NGLYLIYGQV APNANYNDVA PFEVRLYKNK DMIQTLTNKS KIQNVGGTYE LHVGDTIDLI FNSEHQVLKN NTYWGIILLA NPQFI
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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