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TNNC1, Recombinant, Human, aa1-161, His-tag (Troponin C, Slow Skeletal And Cardiac Muscles, TN-C, TNNC)

Cat no: T8665-18R

TNNC1, Recombinant, Human, aa1-161, His-tag (Troponin C, Slow Skeletal And Cardiac Muscles, TN-C, TNNC)

TNNC1, is a member of troponins family. Troponin has 3 subunits, Troponin I(Tn-I), Troponin T(Tn-T) and Troponin C(Tn-C). Tn-I subunit inhibits actomyosin ATPase and Tn-T subunit binds tropomyosin and Tn-C, while Tn-C subunit binds calcium and overcomes the inhibitory action of the troponin complex on actin filaments. TNNC1 is dumbbell-shaped and has a hydrophobic pocket that increases the contractile force of muscle fibers.\n\nSource:\nRecombinant corresponding to aa1-161 from human TNNC1, fused to His-tag at N-terminal expressed in E.coli.\n\nAA Sequence:\nMGSSHHHHHH SSGLVPRGSH MDDIYKAAVE QLTEEQKNEF KAAFDIFVLG AEDGCISTKE LGKVMRMLGQ NPTPEELQEM IDEVDEDGSG TVDFDEFLVM MVRCMKDDSK GKSEEELSDL FRMFDKNADG YIDLDELKIM LQATGETITE DDIEELMKDG DKNNDGRIDY DEFLEFMKGV E\n\nMolecular Weight:\n~20.5kD (MALDI-TOF)\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

T8665-18R

Size

50ug

Form

Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, 1mM DTT, 10% glycerol, 0.1M sodium chloride.

Purity

~95% (SDS-PAGE)

References

1. Wu A H)., et al. (1998) Clin Chem. 44:1198-1208. 2. Hamm C W., et al. (2001) Thromb Res. 103:S63-S69.

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