TOB2 (Protein Tob2, Transducer of erbB-2 2, Protein Tob4, KIAA1663, TOB4, TOBL, TROB2)

Cat no: T7948-20

Supplier: United States Biological

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TOB2 is a 344aa rich novel member of the Tob:BTG1 anti-proliferative family of proteins characterized by similarities in their N-terminal BTG:Tob homology domains. This anti-proliferative protein inhibits cell cycle progression from the G0:G1 to S phases and is involved in cell cycle regulation through interaction with Caf1, a component of the CCR4 transcription factor complex that associates with cyclin-dependent kinases. Recent reports suggest that TOB2 plays important roles in spermatogenesis, embryonic dorsoventral patterning, osteogenesis, T-cell activation, learning and memory and acts primarily as a transcriptional repressor in several signaling pathways. TOB2, a signaling protein, may participate in transcriptional regulation of several genes. It is a regulatory protein ubiquitously expressed in most of the tissues. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human heart lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	T7948-20
Reactivities:	Human, Mouse, Bovine, Canine, Chicken/Bird
Hosts:	Rabbit
Applications:	Western Blot
Size:	100ug
Form:	Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type:	Pab
Isotype:	IgG
Purity:	Purified by Protein A affinity chromatography.
Alternative names:	Transducer of ERBB2, 2
References:	1. Ajima, R. et al. Gene. 253:215-220 (2000). 2. Ikematsu, N. et al. Oncogene. 18:7432-7441, 1999. 3. Jia, S. et al. Dev Dyn. 236:913-921 (2007).4. Kawamura-Tsuzuku, J. et al. Oncogene. 23:6630-6638 (2004).
Additional info:	Recognizes human TOB2. Species Crossreactivity: chicken, chimpanzee, bovine, canine, equine, mouse, orangutan. Species sequence homology: xenopus, zebrafish.

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TOB2 (Protein Tob2, Transducer of erbB-2 2, Protein Tob4, KIAA1663, TOB4, TOBL, TROB2)

Cat no: T7948-20

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