Toll Like Receptor 1 (TLR1) (Biotin)

Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila Toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signalling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. Mammalian responsiveness to some bacterial products may be mediated by combinations of TLRs, for example a co-operative effect is observed between TLR1 and TLR2. TLR1 is expressed by monocytes and dendritic cells.\n\nApplications:\nCan be used for Flow Cytometry.\n\nRecommended Dilution:\nFlow Cytometry: 1:10\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20 degrees C or colder. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

T8050-02B

Size

50ug

Applications

FC

Hosts

Mouse

Reactivities

Hum

Conjugates

Biotin

Form

Supplied as a liquid in PBS, containing 0.02% sodium azide and 0.1% BSA. Conjugated to Biotin.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1

References

1. Wyllie, D et al; Evidence for an accessory protein function for Toll-like receptor 1 in anti-bacterial responses. J Immunol 2000, 165: 7125. 2. Visintin, A et al; Regulation of Toll-like receptors in human monocytes and dendritic cells. J Immunol 2001, 166: 249.

Additional Info

Specific for TLR1. It does not recognize TLR2, TLR4 or TLR4 in association with MD2.