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Toll Like Receptor 12 (Toll-like Receptor 12, Tlr12, Gm1365) (FITC)

Toll Like Receptor 12 (Toll-like Receptor 12, Tlr12, Gm1365) (FITC)

Cat no: T8051-22A

Supplier: United States Biological
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The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLR12 has been cloned that displays a distinct pattern of expression in macrophages and liver, kidney, and bladder epithelial cells. TLR12 does not respond to known TLR ligands. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow Cytometry (Intracellular): 1-2ug/10e6 cells Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
Catalogue number: T8051-22A
Reactivities: Mouse, Rat
Hosts: Rabbit
Applications: Flow Cytometry
Size: 100ug
Form: Supplied as a liquid in 10mM Tris, 150mM sodium chloride, 0.05% sodium azide. Labeled with fluorescein isothiocyanate (FITC).
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Muzio M, Natoli G, Saccani S, Levrero M, and Mantovani A. J. Exp. Med. 187: 2097-2101 (1998). 2. Medzhitov R and Janeway CA. Cell 91: 295-298 (1997). 3. Zhang D, Zhang G, Hayden MS, Greenblatt MB, Bussey C, Flavell RA, Ghosh S. Science. 303(5663):1522-1526 (2004). 4. Yarovinsky F, Zhang D, Andersen JF, Bannenberg GL, Serhan CN, Hayden MS, Hieny S, Sutterwala FS, Flavell RA, Ghosh S, Sher A. Science 308: 1626-1629 (2005).
Additional info: Recognizes mouse TLR12. Species Crossreactivity: rat.

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