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Toll Like Receptor 7 (Toll-like Receptor 7, TLR7, HGNC:15631, UNQ248/PRO285) (FITC)

Toll Like Receptor 7 (Toll-like Receptor 7, TLR7, HGNC:15631, UNQ248/PRO285) (FITC)

Cat no: T8050-72M

Supplier: United States Biological
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The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1) and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described (3). Stimulation of the NFkB signaling pathway by TLR7 suggests that it plays a role in immune response. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow (Intracellular): 0.5-1ug/10e6 cells Optimal dilutions to be determined by the researcher. Positive Control: Human PBMCs Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
Catalogue number: T8050-72M
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Flow Cytometry
Size: 100ug
Form: Supplied as a liquid in 10mM Tris, 150mM sodium chloride, 0.05% sodium azide. Labeled with fluorescein isothiocyanate (FITC).
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Medzhitov R and Janeway CA. Cell 91: 295-298 (1997). 2. Chuang TH and Ulevitch RJ. Biochim. Biophys. Acta 1518 (1-2): 157-161 (2001). 3. Muzio M, Natoli G, Saccani S, Levrero M, and Mantovani A.J. Exp. Med. 187: 2097-2101 (1998).
Additional info: Recognizes human TLR7. Species Crossreactivity: mouse.

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