Home  >  Products  >  Toll Like Receptor 7 (Toll-like Receptor 7, TLR7, HGNC:15631, UNQ248/PRO285) (PE)
Toll Like Receptor 7 (Toll-like Receptor 7, TLR7, HGNC:15631, UNQ248/PRO285) (PE)

Toll Like Receptor 7 (Toll-like Receptor 7, TLR7, HGNC:15631, UNQ248/PRO285) (PE)

Cat no: T8050-72N

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1) and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described (3). Stimulation of the NFkB signaling pathway by TLR7 suggests that it plays a role in immune response. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Flow (Intracellular): 0.5-1ug/10e6 cells Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months at 4 degrees C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Catalogue number: T8050-72N
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Flow Cytometry
Size: 100ul
Form: Supplied as a liquid in PBS, 0.05% sodium azide. Labeled with R-pH ycoerythrin (PE).
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Medzhitov R and Janeway CA. Cell 91: 295-298 (1997). 2. Chuang TH and Ulevitch RJ. Biochim. Biophys. Acta 1518 (1-2): 157-161 (2001). 3. Muzio M, Natoli G, Saccani S, Levrero M, and Mantovani A.J. Exp. Med. 187: 2097-2101 (1998).
Additional info: Recognizes human TLR7. Species Crossreactivity: mouse.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave