Toll-Like Receptor 8 Monoclonal Antibody (Clone 44C143)

Antigen: peptide from human TLR8 within the region of amino acids 750-850 . Host: mouse, clone 44C143 . Cross Reactivity: (+) human and mouse TLR8 . Application(s): FC (intracellular and cell surface), IHC (paraffin-embedded sections), and WB . TLRs mediate innate immunity that is essential for microbial recognition. The TLR8 gene contains three exons, two of which have coding function.

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SPECIFICATIONS

Catalog Number

13592

Applications

FC, IHC, WB

Hosts

Mouse

Form

1 ea

P Type

Antibodies

Weight

0

Antigen

synthetic peptide from human TLR8 within the region of amino acids 750-850

Isotype

IgG1k

Storage Temp

-20

Shipping Temp

-20

Additional Info

The toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Like their counterparts in Drosophila, TLRs signal through adaptor molecules. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition. Most mammalian species have between ten and fifteen types of TLRs. Ten functional TLRs (TLR1-10) have been identified in human. Humans also encode a TLR11 gene but it contains several stop codons and protein is not expressed. However, mouse and rat TLR11 are functional, and it is thought that human TLR11 function was lost during evolution. Historically speaking, TLR expression has been most extensively studied in the immune system. Overall, TLRs are highly expressed in immune competent cells, including macrophages, dendritic cells, neutrophils, mucosal epithelial cells and dermal endothelial cells. However, TLRs have also been identified in many other cell types and anatomical tissue locations where they are expressed either constitutively or induced during infection. The TLR8 gene contains three exons, two of which have coding function. TLR8 cDNA codes for a protein of approximate molecular weight of 120 kDa.