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Tollip (CT) (Toll interacting protein)

Tollip (CT) (Toll interacting protein)

Cat no: T8063-52C

Supplier: United States Biological
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Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation. This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml Immunohistochemistry: 2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: T8063-52C
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Takeda, K., et al., (2003), "Toll-like receptors", Annu. Rev. Immunol., 21: 335-376. 2. Janeway, C.A., Jr., et al., (2002), "Innate immune recognition", Annu. Rev. Immunol., 20: 197-216. 3. McGettrick, A.F., et al., (2004), "The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction", Mol. Imm. 41: 577-582. 4. Zhang, G., et al., (2002), "Negative regulation of Toll-like receptor-mediated signaling by Tollip", J. Biol. Chem., 277: 7059-7065.
Additional info: Recognizes Toll Interacting Protein (TOLLIP) C-terminal

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