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Tollip (Toll interacting protein)

Tollip (Toll interacting protein)

Cat no: T8063-52D

Supplier: United States Biological
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TOLLIP is a 30kD adaptor molecule for Toll-like receptors, transducing signals and activating kinases and transcription factors in response to an infection. It is thought to inhibit IRAK-1 activity. This facilitates the termination of the IL-1RI-, TLR2- and TLR4-triggered, NF-kB and JNK signalling pathways during inflammation. Furthermore, TOLLIP is also thought to form a complex with Tom1, which regulates endosomal trafficking of ubiquitinated proteins. Unlike most other inflammation suppressors, TOLLIP is constitutively expressed. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8063-52D
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Bulut, Y. et al. (2001) Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling. J. Immunol. 167:987-94. 2. Didierlaurent, A. et al. (2006) Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide. Mol. Cell. Biol. 26:735-42.
Additional info: Recognizes human TOLLIP. Species Crossreactivity: mouse, rat.

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