TOP3B, CT (TOP3B, TOP3B1, DNA topoisomerase 3-beta-1, DNA topoisomerase III beta-1) (Biotin)

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described.\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

043130-Biotin

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Conjugates

Biotin

Form

Supplied as a liquid in PBS, pH 7.2. Contains ~0.09% sodium azide. Conjugated to Biotin.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Oliveira-Costa, J.P., et al. Hum. Pathol. 41(11):1624-1630(2010)\nLesch, K.P., et al. J Neural Transm 115(11):1573-1585(2008)\nCho, Y.H., et al. Biochim. Biophys. Acta 1679(3):272-278(2004)\nLehner, B., et al. Genome Res. 14(7):1315-1323(2004)\nCollins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :

Additional Info

Human, mouse

Alternative Names

TOP3B, TOP3B1, DNA topoisomerase 3-beta-1, DNA topoisomerase III beta-1