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TORC2 (CREB-regulated Transcription Coactivator 2, Transducer of Regulated cAMP Response Element-binding Protein 2, TORC-2, Transducer of CREB Protein 2, CRTC2)

TORC2 (CREB-regulated Transcription Coactivator 2, Transducer of Regulated cAMP Response Element-binding Protein 2, TORC-2, Transducer of CREB Protein 2, CRTC2)

Cat no: T8067-21E

Supplier: United States Biological
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The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Hormonal and energy-sensing pathways converge on the coactivator TORC2 (transducer of regulated CREB activity 2) to modulate glucose output. Sequestered in the cytoplasm under feeding conditions, TORC2 is dephosphorylated and transported to the nucleus where it enhances CREB-dependent transcription in response to fasting stimuli. Conversely, signals that activate AMPK attenuate the gluconeogenic programme by promoting TORC2 phosphorylation and blocking its nuclear accumulation. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:32,000 Western Blot: 0.3-1ug/ml, observed in lysates of cell line Jurkat on ~85kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8067-21E
Reactivities: Human, Mouse, Rat, Bovine, Canine, Porcine
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes human CRTC2. Species sequence homology: Bovine, canine, mouse, porcine and rat.

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