Toxoplasma gondii, ROP4 (RH2), Recombinant

Toxoplasma is a crescent shaped sporozoan that lives as intracellular parasite in various tissues of vertebrates and completes its life cycle in a single host. It is transmitted via raw/undercooked meat, contaminated soil, or by direct contact. Infection due to Toxoplasma gondii usually occurs in pregnant women where a variable degree of immunosuppression may exist or in patients receiving immunosuppressive drug therapy following organ transplant. Toxoplasma infects tissue of the GI tract where an active infection is accompanied by fever and enlargement of the spleen. Symptoms of toxoplasmosis are generally mild but severe infection of lymph nodes may occur. Congenital toxoplasmosis, in which the maternal infection is transmitted during pregnancy, can produce blindness or mental retardation in the newborn.\n\nE.coli derived recombinant. The artificial mosaic protein contains the Rhoptry protein ROP4 immunodominant regions.\n\nSpecificity: \nImmunoreactive with sera of Toxoplasma gondii-infected individuals.\n\nApplication: \nAntigen in ELISA and Western blots, excellent antigen for detection of Toxoplasma gondii- with minimal specificity problems.\n\nStorage: \nProtein is shipped at ambient temperature. Upon arrival, Store at -200C.\n\nStability: \nFive years frozen. One month in solution at room temperature.

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SPECIFICATIONS

Catalog Number

T8076-40

Size

100ug

Form

Supplied as a liquid in 50mM Tris-HCl, 1.5M urea and 50% glycerol.

Purity

(same/more than) 95% as determined by RP-HPLC, anion-exchange FPLC and/or reducing and non-reducing SDS-PAGE Silver Stained gel.

References

1. Prevalence of Toxoplasma gondii antibodies in rabbits (Oryctolagus cuniculus) from Mexico.\n\nJ Parasitol 2006 Apr;92(2):394-5\n\n2. Serologic survey for Toxoplasma gondii and Neospora caninum in the common brushtail possum (Trichosurus vulpecula) from urban Sydney, Australia.\n\nJ Parasitol 2006 Apr;92(2):267-72\n\n3. Toxoplasma gondii infection reveals a novel regulatory role for galectin-3 in the interface of innate and adaptive immunity.\n\nAm J Pathol 2006 Jun;168(6):1910-20\n\n4. Biological role of surface Toxoplasma gondii antigen in development of vaccine.\n\nWorld J Gastroenterol 2006 Apr 21;12(15):2363-8\n\n5. Dynamic observation of polypide in semen and blood of rabbits infected with Toxoplasma tachyzoites.\n\nChin Med J (Engl) 2006 Apr 20;119(8):701-4\n\n6. Toxoplasma gondii sequesters lysosomes from mammalian hosts in the vacuolar space.\n\nCell 2006 Apr 21;125(2):261-74