Toxoplasma gondii, Tachyzoites

Toxoplasma gondii is a causitive agent of toxoplasmosis in many species of warm blooded animals. Felids are the only definitive host for T. gondii. Infection is usually sub-clinical with symptoms depending on the level of tachyzoite release, the ability of the host to limit tachyzoite spread and the organs damaged by the tachyzoites. Immunocompetent adult animals generally limit tachyzoite spread and infection remains subclinical. However in young or immunocompromised animals infection can develop to an acute gereralised toxoplasmosis. T. gondii is an important zoonotic agent with up to 60% of some human populations demonstrating Serum IgG titers to the organism. These are likely to be persistently infected. The organism is of particular concern in immunocomprimised individuals such as those with HIV infection, who become increasingly susceptible to the organism as the immune system wanes. Infection is also of considerable concern in pregnant women as it can migrate across the placenta and cause birth defects in human foetuses.\n\nApplications: \nSuitable for use in Immunofluorescence. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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