Home  >  Products  >  TRAF1 (TNF Receptor Associated Factor 1, TNF Receptor-associated Factor 1, TRAF 1, TRAF-1, 4732496E14Rik, Epstein-Barr Virus-induced Protein 6, EBV-induced Protein 6, EBI6, MGC-10353)
TRAF1 (TNF Receptor Associated Factor 1, TNF Receptor-associated Factor 1, TRAF 1, TRAF-1, 4732496E14Rik, Epstein-Barr Virus-induced Protein 6, EBV-induced Protein 6, EBI6, MGC-10353)

TRAF1 (TNF Receptor Associated Factor 1, TNF Receptor-associated Factor 1, TRAF 1, TRAF-1, 4732496E14Rik, Epstein-Barr Virus-induced Protein 6, EBV-induced Protein 6, EBI6, MGC-10353)

Cat no: T8171-92C

Supplier: United States Biological
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The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Positive Control: U937 cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: T8171-92C
Reactivities: Human
Hosts: Goat
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in Tris-saline, pH 7.2. 0.5% BSA, 0.02% sodium azide.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: Su X, Li S, Meng M, Qian W, Xie W, Chen D, Zhai Z, Shu HB. TNF receptor-associated factor-1 (TRAF1) negatively regulates Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling. Eur J Immunol. 2006 Jan;36(1):199-206. PMID: 16323247
Additional info: Species Crossreactivity: Human. Other species not tested. Reactivity based upon sequence homology: Mouse.

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