TRAF2 Binding Protein (TRAF2-binding Protein, T2BP, Putative MAPK-activating Protein PM14, Putative NF-kappa-B-activating Protein 20, TRAF-interacting Protein with Forkhead-associated Domain, TRAF-interacting Protein with FHA Domain-containing Protein A,

T2BP, a novel 184aa protein, is human homolog of mouse Tifa. It consists of a central phosphopeptide-binding FHA domain and a C-terminal TRAF6-binding motif. T2BP mediates multiple protein-protein interactions and plays a significant role in innate immunity, adaptive immunity and inflammation. It interacts with TRAF2 and is involved in TNF-mediated signaling. It induces oligomerization and polyubiquitination of TRAF6 leading to activation of TAK1 and IKK in a proteasome-independent mechanism and mediates NF-kappaB and JNK activation. It enhances IRAK1/TRAF6 interactions and mediates IL-1 signaling suggesting a novel regulation of innate immunity and inflammation.\n\nApplications:\nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:100-1:1000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

T8171-96A

Size

100ul

Applications

ELISA

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid.

P Type

Pab

Purity

Serum

Isotype

IgG

References

1. Kanamori et.al Biochem Biophys Res Commun.,290(3):1108-13 (2002 Jan 25) 2. Hiroshi et.al J. Biol. Chem., 278 (14); 12144-12150 (April 4, 2003) 3. Ea et.al PNAS 101 (43); 15318-15323 (October 26, 2004).

Additional Info

Recognizes human TRAF2 Binding Protein.