TRAF2, NT (Tumor Necrosis Factor Receptor Associated Factor 2)

Description:\nTumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress (1). TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a NF receptor superfamily member involved in inducing B \ncell immunity (2), and are critical for NF-kB activation in mouse B lymphocytes (3). TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells (4). TRAF2 also interacts with the TRFR superfamily member lymphotoxin-b receptor (LTbR) \nin association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac (5). \n \nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 0.5-1ug

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SPECIFICATIONS

Catalog Number

T8171-94C

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a liquid in PBS, pH 7.2, 0.02% sodium azide.\n

P Type

Pab

Purity

Purified by immunoaffinity chromatography.\n

Isotype

IgG

References

1. Arch RH, et al. Genes Dev. 1998; 12:2821-30. 2. van Kooten C and Bancherau J. CD40-CD40 ligand. J. Leukoc. Biol. 2000; 67:2-17. 3. Grech AP, et al., Immunity 2004; 21:629-42. 4. Davies CC, Mak TW, Young LS, et al. Mol. Cell. Biol. 2005; 25:9806-19. 5. Kuai J, Nickbarg E, Wooters J, et al. J. Biol. Chem. 2003; 278:14363-9.

Additional Info

Recognizes human TRAF2. Species Crossreactivity: mouse and rat.