Home  >  Products  >  TRAF6BP (TRAF6 Binding Protein, TRAF6-binding Protein, TRAF6 Binding Protein T6BP, T6BP, CALCOCO3, PRO0105, Tax1 (Human T cell Leukemia Virus Type I) Binding Protein 1, Tax1 Binding Protein 1, Tax1 Binding Protein, TAX1BP1, TAX1BP1 Protein, TXBP151)
TRAF6BP (TRAF6 Binding Protein, TRAF6-binding Protein, TRAF6 Binding Protein T6BP, T6BP, CALCOCO3, PRO0105, Tax1 (Human T cell Leukemia Virus Type I) Binding Protein 1, Tax1 Binding Protein 1, Tax1 Binding Protein, TAX1BP1, TAX1BP1 Protein, TXBP151)

TRAF6BP (TRAF6 Binding Protein, TRAF6-binding Protein, TRAF6 Binding Protein T6BP, T6BP, CALCOCO3, PRO0105, Tax1 (Human T cell Leukemia Virus Type I) Binding Protein 1, Tax1 Binding Protein 1, Tax1 Binding Protein, TAX1BP1, TAX1BP1 Protein, TXBP151)

Cat no: T8172-65A

Supplier: United States Biological
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A TRAF-interacting protein that specifically associates with TRAF6. T6BP shares an overall 50% identity and 59% similarity to a recently identified chicken protein MDP62, which has been implicated in promoting neurite outgrowth. T6BP-TRAF6 complex formation is dependent on the presence of the IL-1 receptor-associated kinase (IRAK). Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Positive Control: Raji Cellular Localization: Nuclear Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: T8172-65A
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: Ling L & Goeddel DV T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Proc Natl Acad Sci U S A 97:9567-72 (2000). Uyeda A et al. Chick muscle-derived protein 62: a novel neurite outgrowth promoting protein. Neurosci Lett 284:61-4 (2000). Darnay BG et al. Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif. J Biol Chem 274:7724-31 (1999).
Additional info: Researchers are encouraged to titer for their specific applications. Species Crossreactivity: Crossreacts with Human. Expected to crossreact with Mouse (95% identity with immunogen) and Rat (95% identity with immunogen) due to sequence homology. Not yet tested in other species.

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