TRAF6BP (TRAF6 Binding Protein, TRAF6-binding Protein, TRAF6 Binding Protein T6BP, T6BP, CALCOCO3, PRO0105, Tax1 (Human T cell Leukemia Virus Type I) Binding Protein 1, Tax1 Binding Protein 1, Tax1 Binding Protein, TAX1BP1, TAX1BP1 Protein, TXBP151)

A TRAF-interacting protein that specifically associates with TRAF6. T6BP shares an overall 50% identity and 59% similarity to a recently identified chicken protein MDP62, which has been implicated in promoting neurite outgrowth. T6BP-TRAF6 complex formation is dependent on the presence of the IL-1 receptor-associated kinase (IRAK).\n\nApplications: \nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nPositive Control: Raji\n\nCellular Localization: Nuclear\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 3 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

T8172-65A

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

References

Ling L & Goeddel DV T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Proc Natl Acad Sci U S A 97:9567-72 (2000). <PUBMED:10920205>Uyeda A et al. Chick muscle-derived protein 62: a novel neurite outgrowth promoting protein. Neurosci Lett 284:61-4 (2000). <PUBMED:10771162>Darnay BG et al. Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif. J Biol Chem 274:7724-31 (1999). <PUBMED:10075662>

Additional Info

Researchers are encouraged to titer for their specific applications. Species Crossreactivity: Crossreacts with Human. Expected to crossreact with Mouse (95% identity with immunogen) and Rat (95% identity with immunogen) due to sequence homology. Not yet tested in other species.