Home  >  Products  >  TRAF7 (TNF Receptor Associated Factor 7, TNF Receptor-associated Factor 7, TRAF 7, TRAF-7, DKFZp586I021, E3 Ubiquitin Protein Ligase TRAF7, MGC7807, Ring Finger and WD Repeat Domain 1, RFWD1, RING Finger Protein 119, RNF119)
TRAF7 (TNF Receptor Associated Factor 7, TNF Receptor-associated Factor 7, TRAF 7, TRAF-7, DKFZp586I021, E3 Ubiquitin Protein Ligase TRAF7, MGC7807, Ring Finger and WD Repeat Domain 1, RFWD1, RING Finger Protein 119, RNF119)

TRAF7 (TNF Receptor Associated Factor 7, TNF Receptor-associated Factor 7, TRAF 7, TRAF-7, DKFZp586I021, E3 Ubiquitin Protein Ligase TRAF7, MGC7807, Ring Finger and WD Repeat Domain 1, RFWD1, RING Finger Protein 119, RNF119)

Cat no: T8172-70A

Supplier: United States Biological
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TRAFs are signal transducers for members of TNFR superfamily. These are critically involved in activation of MAP3K family members involved in NF-kappaB and JNK activation and apoptosis. TRAF7, a novel 670aa protein, is a human homolog of mouse Traf7 and consists of an N-terminal RING finger domain, central TRAF domain, a coiled-coil motif and 7 WD40 repeats at the C-terminus. It has E3-ubiquitin ligase activity for self-ubiquitination. TRAF7 specifically interacts with MEKK3 and mediates MEKK3-induced AP1 and CHOP activation and induces apoptosis through Caspase-independent pathways.It is a multifunctional protein involved in sumoylation and negative regulation of c-Myb, thereby regulating proliferation and differentiation of hematopoietic cells. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 0.1-1ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8172-70A
Reactivities: Human
Hosts: Rabbit
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Xu,L.G., Li,L.Y. and Shu,H.B. TRAF7 potentiates MEKK3-induced AP1 and CHOP activation and induces apoptosis. J. Biol. Chem. (2004) In press. 2. Morita et.al MCB 16 (11); 5433-5444 (November 2005).
Additional info: Recognizes human TRAF7. Species sequence homology: mouse and rat.

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