Home  >  Products  >  TRAIL, CT (TNF-related Apoptosis-inducing Ligand, Apo-2 Ligand, APO2L, Apo-2L, CD253, Protein TRAIL, TL2, Tumor Necrosis Factor Ligand Superfamily Member 10, TNFSF10)
TRAIL, CT (TNF-related Apoptosis-inducing Ligand, Apo-2 Ligand, APO2L, Apo-2L, CD253, Protein TRAIL, TL2, Tumor Necrosis Factor Ligand Superfamily Member 10, TNFSF10)

TRAIL, CT (TNF-related Apoptosis-inducing Ligand, Apo-2 Ligand, APO2L, Apo-2L, CD253, Protein TRAIL, TL2, Tumor Necrosis Factor Ligand Superfamily Member 10, TNFSF10)

Cat no: T8180-06A

Supplier: United States Biological
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Tumor necrosis factor-related apoptosis-inducing ligand (Trail) is one of the several members of the tumor necrosis factor TNF gene superfamily that induce apoptosis through engagement of death receptors (DRs). By interacting with two receptors, named DR4 (death receptor 4 or TRAIL-R1) and DR5 (TRAIL-R2) it initiates the formation of TRAIL DISC, thus induce the apoptosis. In addition, three other receptors, DcR1 (TRAIL-R3), DcR2 (TRAIL-R4), and the soluble TNFR family member osteoprotegerin (OPG) can bind to the TRAIL to act as "decoys". Studies revealed that the TRAIL system is involved in the immune surveillance, tumor initiation and metastasis, and the inhibiting of autoimmune inflammation. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:5000-1:20,000 Western Blot: 1:500-1:1000 Immunohistochemistry: 1:200 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8180-06A
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Pitti RM, et al. J. Biol. Chem. 271: 12687-12690 2. Wiley SR, et al. Immunity 3: 673-682 3. LeBlanc, HN., et al. Cell Death and Differentiation (2003) 10, 66-75.
Additional info: Recognizes human Trail.

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