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TRAIL-R1:Fc, Recombinant, Human (DR4, TNFRSF 10A, APO2, CD261, TRAIL Receptor 1, TNF-related Apoptosis-inducing Ligand Receptor 1)

TRAIL-R1:Fc, Recombinant, Human (DR4, TNFRSF 10A, APO2, CD261, TRAIL Receptor 1, TNF-related Apoptosis-inducing Ligand Receptor 1)

Cat no: 045353

Supplier: United States Biological
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TRAIL-R1 (DR4; CD261) is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB. Biological Activity: Blocks human or mouse TRAIL activity in a concentration of 1-10ug/ml. Sequence: The extracellular domain of human TRAIL-R1 (aa 24-239) is fused to the Fc portion of human IgG1. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Stable for at least 6 months after receipt when stored at -20 degrees C.
Catalogue number: 045353
Size: 50ug
Form: Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.
Purity: >95% (SDS-PAGE)
Alternative names: DR4, TNFRSF 10A, APO2, CD261, TRAIL Receptor 1, TNF-related Apoptosis-inducing Ligand Receptor 1
Additional info: Binds to human and mouse TRAIL.

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