TRAIL, Recombinant, Human (TNF-related Apoptosis-inducing Ligand, Apo-2 Ligand, APO2L, Apo-2L, CD253, Protein TRAIL, TL2, Tumor Necrosis Factor Ligand Superfamily Member 10, TNFSF10)

Human TRAIL (TNF-Related Apoptosis Inducing Ligand), also called Apo2 Ligand (Apo2L), is a cytotoxic protein that activates rapid apoptosis in tumor cells, but not at normal cells. The recombinant human TRAIL/Apo2L is a single polypeptide chain containing 168 amino acids and have a molecular mass of 19.6kD.\n\nSource: \nRecombinant, human TRAIL/Apo2 Ligand expressed in E. coli.\n\nBiological Activity: \nThe activity is determined by its ability to induce apoptotic cell death in TRAIL-sensitive U343MG cells. The ED50 for the effect is 1-3ng/ml.\n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

T8180-15C

Size

10ug

Form

Supplied as a lyophilized powder from 150mM sodium chloride, 50mM sodium phosphate, pH 7.4. Reconstitute with sterile ddH2O to a concentration of 0.5-1mg/ml.

Purity

~98% (SDS-PAGE and HPLC). Endotoxin: (same/less than) 0.1ng/ug.

Alternative Names

h-TRAIL/Apo2, rh-TRAIL/Apo2