Home  >  Products  >  TRAIL (TNF-related Apoptosis-inducing Ligand, Protein TRAIL, Apo-2 Ligand, APO2L, Apo-2L, CD253, TL2, Tumor Necrosis Factor Ligand Superfamily Member 10, TNFSF10) (Low Endotoxin)
TRAIL (TNF-related Apoptosis-inducing Ligand, Protein TRAIL, Apo-2 Ligand, APO2L, Apo-2L, CD253, TL2, Tumor Necrosis Factor Ligand Superfamily Member 10, TNFSF10) (Low Endotoxin)

TRAIL (TNF-related Apoptosis-inducing Ligand, Protein TRAIL, Apo-2 Ligand, APO2L, Apo-2L, CD253, TL2, Tumor Necrosis Factor Ligand Superfamily Member 10, TNFSF10) (Low Endotoxin)

Cat no: T8180-01V

Supplier: United States Biological
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TRAIL is a cytotoxic protein closely related to Fas (CD95), which induces extensive apoptosis in a range of cell types. TRAIL induces apoptosis via the receptors DR4 and DR5. Most normal tissues are resistant to TRAIL induced apoptosis due to their expression of decoy receptors, DcR1 and DcR2, which antagonise TRAIL activity. TRAIL is expressed by cell lines, activated lymphocytes and on syncytiotrophoblast cells in first trimester pregnancy. Applications: Suitable for use in Western Blot and Flow cytometry and functional applications. Other applications have not been tested. Recommended Dilutions: Optimal dilutions to be determined by the researcher. Endotoxin: (same/less than)0.01EU/ug Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8180-01V
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Western Blot
Size: 500ug
Form: Supplied as a liquid in PBS. No preservatives added.
P type: Mab
Isotype: IgG1
Purity: Purified by Protein A affinity chromatography. Endotoxin: <0.01EU/ug
Alternative names: Tumor Necrosis Factor (Ligand) Superfamily, Member 10
References: 1. Plasilova, M. et al. (2002) TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors. Leukemia. 16: 67-73.
Additional info: Recognizes the 281 aa protein human CD253 (TRAIL). Neutralises TRAIL activity.

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