TRAIL (TNF Related Apoptosis Inducing Ligand, TNF-related Apoptosis-inducing Ligand, Protein TRAIL, Apo-2 Ligand, APO2L, Apo-2L, CD253, TL2, Tumor Necrosis Factor Ligand Superfamily Member 10, TNFSF10)

TRAIL, a 32.5kD Type II transmembrane cytokine, is a unique member of TNF super family. It has a major role in antitumor immunosurveillance, mediates thymocyte apoptosis and is important in the induction of autoimmune diseases. It interacts with its receptors including DR4, DR5, TRID:DcR1:TRAILR3, DcR2:TRAILR4 and OPG and induces apoptosis by activating MAPK8:JNK signaling in a Caspase-dependent and independent pathways. Due to its significance as a potent inducer of apoptosis in transformed and tumor cells, TRAIL may be useful in cancer therapy. Northern Blot analysis detected a ubiquitous expression of TRAIL although it doesn

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SPECIFICATIONS

Catalog Number

T8180-07A

Size

100ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.02% sodium azide.

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

References

1. Wiley, S.R. et al. (1995) Immunity. 3(6):673-82 2. Muhlenbeck et.al J Biol Chem., 273 (49); 33091-33098 (Dec 4, 1998) 3. Wang et.al Oncogene 22 (53); 8628-8633 (24 Nov 2003) 4. Robert et.al J Biol Chem., 271 (22); 12687-12690 (May 31, 1996)

Additional Info

Recognizes human TRAIL/Apo-2 Ligand.

Alternative Names

Tumor Necrosis Factor (Ligand) Superfamily, Member 10