Home  >  Products  >  TRAIL (TNF Related Apoptosis Inducing Ligand, TNF-related Apoptosis-inducing Ligand, Protein TRAIL, Apo-2 Ligand, APO2L, Apo-2L, CD253, TL2, Tumor Necrosis Factor Ligand Superfamily Member 10, TNFSF10)
TRAIL (TNF Related Apoptosis Inducing Ligand, TNF-related Apoptosis-inducing Ligand, Protein TRAIL, Apo-2 Ligand, APO2L, Apo-2L, CD253, TL2, Tumor Necrosis Factor Ligand Superfamily Member 10, TNFSF10)

TRAIL (TNF Related Apoptosis Inducing Ligand, TNF-related Apoptosis-inducing Ligand, Protein TRAIL, Apo-2 Ligand, APO2L, Apo-2L, CD253, TL2, Tumor Necrosis Factor Ligand Superfamily Member 10, TNFSF10)

Cat no: T8180-07A

Supplier: United States Biological
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TRAIL, a 32.5kD Type II transmembrane cytokine, is a unique member of TNF super family. It has a major role in antitumor immunosurveillance, mediates thymocyte apoptosis and is important in the induction of autoimmune diseases. It interacts with its receptors including DR4, DR5, TRID:DcR1:TRAILR3, DcR2:TRAILR4 and OPG and induces apoptosis by activating MAPK8:JNK signaling in a Caspase-dependent and independent pathways. Due to its significance as a potent inducer of apoptosis in transformed and tumor cells, TRAIL may be useful in cancer therapy. Northern Blot analysis detected a ubiquitous expression of TRAIL although it doesn
Catalogue number: T8180-07A
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
Alternative names: Tumor Necrosis Factor (Ligand) Superfamily, Member 10
References: 1. Wiley, S.R. et al. (1995) Immunity. 3(6):673-82 2. Muhlenbeck et.al J Biol Chem., 273 (49); 33091-33098 (Dec 4, 1998) 3. Wang et.al Oncogene 22 (53); 8628-8633 (24 Nov 2003) 4. Robert et.al J Biol Chem., 271 (22); 12687-12690 (May 31, 1996)
Additional info: Recognizes human TRAIL/Apo-2 Ligand.

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