Home  >  Products  >  TRAM (C2) (TRIF-related Adapter Molecule, Putative NF-kappa-B-activating Protein 502, TIR Domain-containing Adapter Molecule 2, TICAM2, TICAM-2, Toll/interleukin-1 Receptor Domain-containing Protein, TIRP, Toll-like Receptor Adaptor Protein 3, TIRAP3)
TRAM (C2) (TRIF-related Adapter Molecule, Putative NF-kappa-B-activating Protein 502, TIR Domain-containing Adapter Molecule 2, TICAM2, TICAM-2, Toll/interleukin-1 Receptor Domain-containing Protein, TIRP, Toll-like Receptor Adaptor Protein 3, TIRAP3)

TRAM (C2) (TRIF-related Adapter Molecule, Putative NF-kappa-B-activating Protein 502, TIR Domain-containing Adapter Molecule 2, TICAM2, TICAM-2, Toll/interleukin-1 Receptor Domain-containing Protein, TIRP, Toll-like Receptor Adaptor Protein 3, TIRAP3)

Cat no: T8190-01A

Supplier: United States Biological
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TIRP is a member of the Toll:interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TIRP, along with other molecules such as TRIF, MAL, and MyD88, serves as an adaptor protein that allows for the interaction and activation of the IL-1R-associated kinase (IRAK) family, the subsequent activation of TNF receptor associated factor (TRAF)-6, andultimately the activation of NF-kB. Expression of TIRP appears to be essential for TLR4 signalling. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Immunohistochemistry (paraffin): 2ug/ml Optimal dilutions to be determined by the researcher. Positive Control: Human (A), mouse (B), and rat (C) kidney cell lysates. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8190-01A
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified
Alternative names: MGC129876, MGC129877, Toll-like Receptor Adaptor Molecule 2
References: 1. O
Additional info: Recognizes human TIRP (C2). Species Crossreactivity: mouse and rat.

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