Home  >  Products  >  TRAM (TRIF-related Adapter Molecule, Putative NF-kappa-B-activating Protein 502, TIR Domain-containing Adapter Molecule 2, TICAM2, TICAM-2, Toll/interleukin-1 Receptor Domain-containing Protein, TIRP, Toll-like Receptor Adaptor Protein 3, TIRAP3)

TRAM (TRIF-related Adapter Molecule, Putative NF-kappa-B-activating Protein 502, TIR Domain-containing Adapter Molecule 2, TICAM2, TICAM-2, Toll/interleukin-1 Receptor Domain-containing Protein, TIRP, Toll-like Receptor Adaptor Protein 3, TIRAP3)

Cat no: T8190-01


Supplier: United States Biological
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TRAM, or TRIF-related adaptor molecule, plays an essential role in the MyD88-independent signaling of TLR4. The functional absence of TRAM in vascular endothelial cells restricts TLR4 signaling to MyD88-dependent pathway. Overexpression of TRAM cDNA in endothelial cells reconstituted LPS-induced Trif-dependent NF-
Catalogue number: T8190-01
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein A affinity chromatography.
Alternative names: MGC129876, MGC129877, Toll-like Receptor Adaptor Molecule 2
References: 1. Fitzgerald, K. et al. J. Exp. Med. 198:1043-1055 (2003). 2. Yamamoto, M. et al. Nat. Immunol. 4:1144-1150 (2003). 3. Harari, A.O. et al. Circ. Res. 98:1134-1140 (2006).
Additional info: Recognizes human TRAM. Species Crossreactivity: chimpanzee, rhesus monkey. Species sequence homology: mouse, rat, canine, equine.

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