TRAM (TRIF-related Adapter Molecule, TIRP, Toll-Interleukin 1 Receptor Domain-containing Protein, TICAM-2, TIR-containing Adapter Molecule-2)

TRAM functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. It is also involved in IL-1-triggered NF-kappaB activation, functioning upstream of IRAK1, IRAK2, TRAF6 and IKBKB. TRAM physically bridges TLR4 and TICAM-1 and functionally transmits LPS-TRL4 signal to TICAM-1. It is expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle and pancreas.\n\nApplications:\nSuitable for use in Western Blot\n\nRecommended Dilution:\nOptimal dilutions to be determined by researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

045372

Size

50ul

Applications

WB

Hosts

Rabbit

Form

Neat serum 0.02% sodium azide.

P Type

Pab

References

Product Reference: \n?Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells: E. Aksoy, et al.; Blood 109, 2887 (2007) \n?

Additional Info

Recognizes human TRAM.

Alternative Names

TRIF-related Adapter Molecule, TIRP, Toll-Interleukin 1 Receptor Domain-containing Protein, TICAM-2, TIR-containing Adapter Molecule-2