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trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene

trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene

Cat no: 166866

Supplier: United States Biological
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trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene is a metabolite of Benzopyrene (B205800). Benzo[a]pyrene (B205800), a prototypic PAH, is metabolized by cytochrome P 450 1A1/1B1. (-)-trans-7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene (D452280) undergoes further P 4501A1/1B1-mediated metabolism to a carcinogen, which forms DNA-adducts primarily with 2'-deoxyguanosine. A carcinogen. Melting Point: >158 degrees C (dec.) Solubility: DMSO, Methanol, THF
Catalogue number: 166866
Size: 2.5mg
Form: Supplied as a Brown Solid
Alternative names: (
References: Gelhaus, S. et al: Chem. Res. Toxicol., 24, 89 (2011); Belvedere, G. et al.: Biochem. Pharmacol., 29, 1693 (1980); Jennette, K. et al.: Biochem. Pharmacol., 28, 338 (1979); Yagi, H. et al.: J. Am. Chem. Soc., 99, 2358 (1977)

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