Home  >  Products  >  Transcription Factor 7 (TCF7, (T-cell Specific, HMG-box), FLJ36364, MGC47735, T-cell Factor 1, T-cell-specific Transcription Factor 1, TCF1, TCF-1, Transcription Factor 7)
Transcription Factor 7 (TCF7, (T-cell Specific, HMG-box), FLJ36364, MGC47735, T-cell Factor 1, T-cell-specific Transcription Factor 1, TCF1, TCF-1, Transcription Factor 7)

Transcription Factor 7 (TCF7, (T-cell Specific, HMG-box), FLJ36364, MGC47735, T-cell Factor 1, T-cell-specific Transcription Factor 1, TCF1, TCF-1, Transcription Factor 7)

Cat no: T8195-36

Supplier: United States Biological
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TCF7 (Transcription factor 7; also T cell factor 1/TCF1) is a 25-50kD member of the lymphoid enhancer binding factor family of proteins with 16 isoforms. It is expressed in thymocytes and mature T cells, and serves multiple purposes. In resting cells, TCF family members are transcriptional repressors, and are 25-32kD in size. Following activation, large TCF7 isoforms predominate (42-50kD), and serve a transcriptional activator function. Human TCF7 is 384aa in length. This is likely an activating isoform that contains a beta-catenin binding domain (aa1-59), a DNA-binding HMG-box (aa269-337), and an NLS (aa344-348). The use of an alternate start site at Met116 seems to characterize repressor isoforms. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile 40-50% glycerol, PBS.. Aliquot and store at -20 degrees C. Reconstituted product is stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: T8195-36
Reactivities: Human
Hosts: Goat
Applications: Western Blot
Size: 100ug
Form: Supplied as a lyophilized powder in 0.2um sterile-filtered solution in PBS 5% trehalose. Reconstitute with 40-50% glycerol, PBS.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Additional info: Recognizes human TCF7/TCF1 at~60, 40, and 38kD.

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