Transferrin Receptor, soluble, Human, Native (TfR1, TFRC, CD71, TR, Tfr, TfnrR, sTfR)

Purified Human soluble Transferrin receptor (TfR1) protein.\n\nThe transferrin receptor (TfR) is the gateway for transferrin-bound-iron entering all body cells. TfR is abundant on the surface of many newly formed cells, but the erythroid narrow cells account for 70 to 80% of the total body TfR content. The soluble (or serum) transferrin receptor (sTfR) is a circulating truncated form of the membrane receptor protein; it is an 85kD glycoprotein forming in serum a 320kD complex with diferric transferrin. The serum sTfR concentration reflects the total body mass of cellular transferrin receptor. Anemias associated with enhanced erythropoiesis and iron deficiency result in an elevation in the sTfR values. The normal sTfR concentrations are about 0.8-2.3ug/ml for adults, the iron deficiency may increase the values up to 20 fold. \n\nElevation of the soluble transferrin receptor may be also caused by hemolytic anaemia, polycythemia and thalassemia while aplastic anemia and chronic renal failure may result in decrease. The most important clinical use of the sTfR determination is in the differential diagnosis between iron deficiency anemia and the anemia of chronic disease.\n\nMolecular Weight: ~80kD\n\nApplications: \nSuitable for use as a marker of iron deficiency anemia to differentiate it from anemia of chronic disease. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

T8199-45D

Size

100ug

Form

Supplied as a lyophilized powder from 10mM Tris HCl, 0.15M NaCl, 5% mannitol, 0.1% CHAPS. Reconstitute with deionized water. Do not freeze after reconstitution.

Purity

Highly purified (same/more than) 95% (SDS-PAGE). Concentration has been determined using Lowry method (Sigma). Immunological identity confirmed by reaction with monoclonal antibodies specific to human soluble transferrin receptor.