Transferrin Receptor, soluble (sTfr)

Transferrin receptor is a 190kD Type II membrane glycoprotein which consists of two subunits of 95kD. It is expressed on activated lymphocytes, macrophages and monocytes. It binds Fe (Apo) transferrin. The gene coding for the antigen is located on the q-arm of chromosome 3. The ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias and lymphomas. Transferrin receptors are also present on reticulocytes, but are lost during maturation into erythrocytes.Transferrin receptor (CD71) has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer. The transferrin receptor has been structurally characterized as a disulfide-bound dimer of identical glycoprotein subunits of 95kDa. The transferrin receptor is not present on resting peripheral blood lymphocytes, but appears after mitogenic stimulation on B and T cells. Erythroblasts express high levels of CD71. It is also present on macrophages. It is expressed by some T-and B-cell lines. CD71 expression is linked to cell proliferation and intracellular iron concentration. Has been studied at the Vth International Workshop on Human Leukocyte Differentiation Antigens in Boston (1993). Cell surface expression of transferrin receptors is correlated with relative cell growth rate of malignant and non-malignant cells. Transferrin receptors are virtually absent from resting PBL

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