Transferrin (Tf)

Transferrin is a single polypeptide chain glycoprotein. It is a member of the iron binding family of proteins. It has a molecular weight of 79.5kD and a serum concentration range of 1800-2700mg/L. It is synthesized in the liver and consists of two domains each having a high affinity reversible binding site for Fe3+. The iron is transported in blood and interstitial fluids to sites of use and disposal. Iron/transferrin is essential in hemoglobin synthesis and for certain types of cell division. Serum concentration rises in iron deficiency and pregnancy and falls in iron overload, infection and inflammatory conditions.\n\nApplications: \nSuitable for use in Immunodiffusion. Other applications not tested.\n\nRecommended Dilution:\nImmunodiffusion: neat\nOptimal dilutions to be determined by the researcher.\n\nRecommended Secondary Antibodies: \nI1904-63 IgG, H&L (HRP) Pab DkxSh\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

T8199-04A

Size

1ml

Hosts

Sheep

Reactivities

Hum, Mouse, Rat, Fel, GP, Rabbit

Form

Supplied as a liquid in GBS, pH 7.4, 0.1% sodium azide, 0.1% EACA, 0.01% Benzamidine, 1mM EDTA.

P Type

Pab

Purity

Purified by ion exchange chromatography.

Isotype

IgG

Additional Info

Recognizes human transferrin, an iron binding glycoprotein of 79kD. Species Crossreactivity: Feline, mouse, rat, rabbit, guinea pig. Does not crossreact with chicken, bovine, equine, goat, canine or porcine.