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Transforming Growth Factor alpha (TGFa)

Cat no: T8250-10

Transforming Growth Factor alpha (TGFa)

TGF-alpha (transforming growth factor alpha) is a 50aa EGF-related polypeptide expressed in a range of tissues, including skin, pancreas, liver, duodenum, salivary glands, urinary and respiratory systems, and the developing and mature central nervous system (CNS). TGF-alpha is produced by monocytes, keratinocytes and neuronal cells and stimulates the proliferation of a range of epidermal and epithelial cells, through binding to the epidermal growth factor receptor (EGFR). TGF-alpha is mitogenic for multipotent neural progenitors and is involved in astrogliosis.\n\nApplications: \nSuitable for use in ELISA and Neutralization. Other applications have not been tested. \n\nRecommended Dilution: \nOptimal dilutions to be determined by researcher. \n\nStorage and Stability:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

T8250-10

Size

500ug

Applications

ELISA

Hosts

Goat

Reactivities

Hum

Form

Supplied as a lyophilized powder from PBS, pH 7.5, 5% trehalose. Reconstitute with sterile PBS.

P Type

Pab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG

Additional Info

Recognizes human TGF alpha: 100%. No crossreactivty to other cytokines such as hTGFbeta, hEGF, hPDGf, hTNF. hEPO, hIGF, hIL-1, hIL-2, hIL-3, hIL-4, hIL-5 , hIL-6, hIL-7, hIL-8, hIL-9, hIL-10, hIL-11,and hIL-12.

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