Transforming Growth Factor beta 1 (TGFb1, TGF-beta-1, TGFB1, TGFB) (APC)

TGF-b is synthesized as high molecular weight latent complexes. In platelets, the large latent TGF-b1 complex is composed of three components: mature TGF-b1 dimer, latency associated peptide, and latent TGF-b binding protein (LTBP). The cDNAs for four binding proteins (LTBP-1,-2,-3 and-4) have now been cloned.\n \nApplications:\nSuitable for use in Flow Cytometry. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nHybridoma:\nFusion of a mouse myeloma with B cells obtained from a mouse immunized with partially purified, large latent transforming growth factor beta 1 complex from human platelets. \n\nStorage and Stability:\nMay be stored at 4 degrees C before opening. DO NOT FREEZE! Stable at 4 degrees C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Freezing APC conjugates will result in a substantial loss of activity. APC conjugates are sensitive to light.

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SPECIFICATIONS

Catalog Number

T8250-16F

Size

100Tests

Applications

FC

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in 1ml saline, 0.5% BSA, 0.1% sodium azide. Labeled with Allophycocyanin (APC).

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1

References

1. Miyazono, K. et al. (1991) EMBO J. 10:1091. 2. Moren, A. et al. (1994) J. Biol. Chem. 269:32469. 3. Yin, W. et al. (1995) J. Biol. Chem. 270:10147. 4. Kanzaki, T. et al. (1990) Cell 61:1051. 5. Saharinen, J. et al. (1998) J. Biol. Chem. 273:18459.

Additional Info

Recognizes human latent TGF-b.