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Transforming Growth Factor beta Induced, 502-683aa, Recombinant, Human (BIGH3, TGFBI, ig-h3)

Cat no: T8252-90A


Supplier: United States Biological
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BIGH3, also known as TGFBI and Beta ig-h3, is an extracellular matrix protein induced by transforming growth factor(TGF)-beta 1. BIGH3 protein is involved in cell growth, cell differentiation, wound healing and cell adhesion. In addition, some missense mutations of BIGH3 were identified in families affected with human autosomal dominant corneal dystrophies. BIGH3 gene encodes for a 683 amino-acid protein containing an RGD motif and four internal repeated domains which have highly conserved sequences founded in several species (Fasciclin domain). Recombinant human BIGH3 protein was expressed in E. coli and purified by using conventional chromatography techniques. Endotoxin Level: (same/less than)1EU/ug (LAL) Molecular Weight: 19.9kD (182 aa) Amino Acid Sequence: MGTVMDVLKG DNRFSMLVAA IQSAGLTETL NREGVYTVFA PTNEAFRALP PRERSRLLGD AKELANILKY HIGDEILVSG GIGALVRLKS LQGDKLEVSL KNNVVSVNKE PVAEPDIMAT NGVVHVITNV LQPPANRPQE RGDELADSAL EIFKQASAFS RASQRSVRLA PVYQKLLERM KH Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: T8252-90A
Size: 100ug
Form: Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 1mM EDTA, 0.1mM PMSF, 20% glycerol.
Purity: (same/more than)95% by SDS-PAGE.
Alternative names: Beta ig-h3, TGFBI, Kerato-epithelin, RGD-CAP
References: 1. Billings PC., et al. (2002) J Biol Chem. 277, 28003-9. 2. Munier FL., et al. (2002) Invest Ophthalmol Vis Sci. 43, 949-54. 3. Kim JE., et al. (2000) J Biol Chem. 275, 30907-15.

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