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Transforming Growth Factor beta Induced (BIGH3, TGFBI, Beta-ig-h3)

Transforming Growth Factor beta Induced (BIGH3, TGFBI, Beta-ig-h3)

Cat no: T8252-92

Supplier: United States Biological
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This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. Applications: Suitable for use in ELISA and Western Blot. Other applications have not been tested. Recommended Dilutions: Peptide ELISA Titer: 1:32,000 Western Blot: 0.2-0.5ug/ml. ~70kD band observed in Human, Mouse and Rat Kidney lysates (calculated MW of 74.7kD according to Human NP_000349.1). Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: T8252-92
Reactivities: Human
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by peptide affinity chromatography.
Alternative names: TGFBI, transforming growth factor, beta-induced, 68kDa, RGD-containing collagen-associated protein, LCD1, kerato-epithelin, EBMD, CSD3, CSD2, CSD1, CSD, CDGG1, CDG2, CDB1, BIGH3
References: 1. Zenteno JC, Correa-Gomez V, Santacruz-Valdez C, Suarez-Sanchez R, Villanueva-Mendoza C, Clinical and genetic features of TGFBI-linked corneal dystrophies in Mexican population: description of novel mutations and novel genotype-phenotype correlations. Experimental eye research 2009 Aug 89 (2): 172-7
Additional info: Recognizes human TGFB1. Species sequence homology: mouse, rat, canine.

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