Transforming Growth Factor beta1 (TGF beta 1, TGFb1, Camurati Engelmann Disease, CED, Diaphyseal Dysplasia 1 Progressive, DPD1, TGFb1, Differentiation inhibiting factor, Cartilage-inducing factor) (Biotin)

TGFb1 is one of three closely related mammalian members of the large TGF-b superfamily that share a characteristic cystine knot structure. TGFb1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial

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SPECIFICATIONS

Catalog Number

T8250-16B

Size

50ug

Applications

ELISA, WB

Hosts

Ch/Bird

Reactivities

Hum, Mouse

Conjugates

Biotin

Form

Supplied as a lyophilized powder from PBS, pH 7.4, 2.5mg BSA. Labeled with Biotin. Reconstitute with sterile 250ul PBS.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgY

References

1. Derynck, R. and K. Miyazono (2008) Cold Spring Harbor Laboratory Press, 29. 2. Dunker, N. and K. Krieglstein (2000) Eur. J. Biochem. 267:6982. 3. Wahl, S.M. (2006) Immunol. Rev. 213:213. 4. Chang, H. et al. (2002) Endocr. Rev. 23:787. 5. Lin, J.S. et al. (2006) Reproduction 132:179. 6. Hinck, A.P. et al. (1996) Biochemistry 35:8517. 7. Mittl, P.R.E. et al. (1996) Protein Sci. 5:1261. 8. Derynck, R. et al. (1985) Nature 316:701. 9. Miyazono, K. et al. (1988) J. Biol. Chem. 263:6407. 10. Oklu, R. and R. Hesketh (2000) Biochem. J. 352:601. 11. de Caestecker, M. et al. (2004) Cytokine Growth Factor Rev. 15:1. 12. Zuniga, J.E. et al. (2005) J. Mol. Biol. 354:1052.

Additional Info

Recognizes human TGFb1. When used in combination with the monoclonal capture antibody T8250-16 in a sandwich ELISA, ~5% crossreactivity with TGF-b1.2 and 1% crossreactivity with recombinant human TGF-b2, recombinant chicken TGF-b3 and recombinant amphibian TG-b5 is observed.